Phospho-STAT1 refers to the phosphorylated form of STAT1, a member of the STAT protein family. It plays a key role in signal transduction and transcriptional activation in response to cytokines and growth factors. Phospho-STAT1 is involved in immune responses to various pathogens and mediates the expression of genes important for cell viability.
7 answers
SolitudePulse
Mon Nov 11 2024
Following dimerization, Stat1 undergoes nuclear translocation. This involves the movement of the dimer from the cytoplasm to the nucleus of the cell.
Valentino
Mon Nov 11 2024
In the majority of cells, both isoforms are activated by interferon-alpha (IFN-α).
CryptoVeteran
Mon Nov 11 2024
In the nucleus, the Stat1 dimer binds to specific DNA sequences.
Federico
Mon Nov 11 2024
Stat1 protein exists in two isoforms, namely Stat1α and Stat1β.
ShintoMystical
Mon Nov 11 2024
Phosphorylation of Stat1 at the Tyr701 residue triggers a series of biological events.