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What is STAT1 gain of function immunodeficiency?
What is STAT1 gain of function immunodeficiency?
Elena
Wed Nov 06 2024
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6 answers
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I'm trying to understand STAT1 gain of function immunodeficiency. Could you explain what it is and how it affects the immune system?
6 answers
GangnamGlamour
Fri Nov 08 2024
Mutations in STAT1-GOF result in alterations in the phosphorylation status of STAT1.
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SamuraiCourage
Fri Nov 08 2024
These mutations lead to an increase in the phosphorylation of STAT1, also known as pSTAT1.
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SakuraSpiritual
Thu Nov 07 2024
Additionally, there is a delay in the dephosphorylation process, causing pSTAT1 to remain activated for longer periods.
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Eleonora
Thu Nov 07 2024
Furthermore, nuclear dephosphorylation of STAT1 is also impaired due to these mutations.
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SeoulStyle
Thu Nov 07 2024
Consequently, the normal development of T helper (Th) 17 cells is hindered, affecting their ability to function properly.
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