When comparing the safety of Trezor and Ledger, both hardware wallets offer high levels of security for storing cryptocurrencies. Trezor is known for its open-source nature, while Ledger emphasizes its proprietary closed operating system and security element chip. Ledger also has a broader range of coin support and additional features like Bluetooth on some models. Ultimately, the choice between Trezor and Ledger depends on user preferences and specific needs.