What is the function of OGN?

OGN, a vital molecule, exerts a pivotal function in suppressing angiogenesis triggered by ischaemia. Its mechanism lies in the inhibition of VEGF-VEGFR2 signaling pathway, a crucial regulator of blood vessel growth.

By inhibiting this pathway, OGN effectively dampens the formation of tubes by endothelial cells, which are essential for the development of new blood vessels. This action underscores OGN's antagonistic role in the angiogenesis process.

Furthermore, OGN inhibits the proliferation and migration of endothelial cells, two key processes necessary for the expansion and extension of blood vessel networks. This dual inhibitory effect underscores OGN's potency in modulating angiogenesis.

In a recent study, researchers have identified a novel form of OGN, a 72-kDa chondroitin sulfate-OGN variant, which exhibits specificity towards innate immune cells. This discovery sheds new light on the potential role of OGN in immune regulation.

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