What is the difference between RTS CTS and Xon Xoff?

Could you please elaborate on the differences between RTS/CTS and Xon/Xoff? I understand they are both Flow control mechanisms used in serial communication, but I'm curious about their specific functions and how they differ from each other. For instance, what scenarios are they typically used in, and how do they help to prevent data loss or overflow? Additionally, are there any advantages or disadvantages to using one over the other? Thank you for your insights.