What strain will knock you out?

Excuse me, but could you please elaborate on the phrase 'What strain will knock you out?' Are you referring to a particular type of cannabis strain, perhaps one known for its potent sedative effects? Or is this a metaphorical question, alluding to a situation where a certain financial or emotional pressure might cause someone to feel overwhelmed or incapacitated? I'm curious to understand the context in which this question is being posed, as it seems to encompass both the realms of finance and potentially, recreational substances. Could you provide some clarification?