Is it bad to leave PC on 24/7?

Is it really detrimental to keep a personal computer operational on a 24/7 basis? Could this constant usage lead to hardware degradation or increased energy consumption? Are there any potential risks associated with leaving a PC running continuously, such as overheating or security vulnerabilities? It's essential to consider these factors when deciding whether to leave a computer running all the time, especially in the context of cryptocurrency mining or other resource-intensive activities.