When should kava be avoided?

Excuse me, I was reading about the use of KAVA and I came across a mention that there are certain situations where it should be avoided. Could you elaborate on when it's advisable to steer clear of kava? Are there specific health conditions or medications that could interact negatively with it? Additionally, are there any known side effects that should raise concern for individuals considering its consumption? I'm interested in understanding the potential risks and limitations of this herbal remedy.