Can you get in trouble for online gambling in us?

I'm curious, can you potentially face legal consequences for engaging in online gambling activities within the United States? I understand that gambling laws vary by state, but are there any overarching federal regulations that could lead to trouble for individuals who choose to participate in online gambling? I'm specifically interested in understanding if there are any penalties or fines associated with this practice. Additionally, are there any exceptions or loopholes that individuals can utilize to gamble online legally within the US?