Can you pull fuse out with hand?

Excuse me, I'm curious about the safety precautions involved in handling fuses. Specifically, is it SAFE to attempt to pull out a fuse with one's bare hand? I understand that electrical components can be hazardous, and I'm concerned about the potential for shock or injury if proper precautions aren't taken. Could you please elaborate on the proper way to handle and remove fuses, and whether or not it's advisable to do so without the use of protective gloves or other safety equipment? Thank you for your time and expertise.