Is Godric's Great Rune permanent?

I'm curious, is Godric's Great RUNE truly a permanent addition to one's magical arsenal? Could it be lost or somehow negated, or is it etched into the fabric of one's being, forever imbuing them with its power? It's an intriguing concept, and I'd love to know if there are any limitations or contingencies to consider when relying on such a formidable magical artifact.