Can you buy an NFT with real money?

Excuse me, I was wondering if I could clarify something about NFTs. Is it possible to purchase an NFT with real money, or do I need to use some form of cryptocurrency? I've heard that NFTs are a popular way to invest in digital art and collectibles, but I'm not entirely sure how the purchasing process works. Could you provide some insight into this, and perhaps explain the different methods of payment that are typically accepted for NFTs? Thank you for your time.