Can I leave two kittens alone?

Hello, I'm curious about leaving my two kittens alone. I understand that cats are often considered independent creatures, but as a responsible pet owner, I want to ensure their well-being. Can I safely leave my kittens unsupervised for extended periods? Are there any specific concerns I should be aware of, such as potential boredom, hunger, or safety hazards? Additionally, what steps can I take to ensure they are comfortable and content while I'm away? Thank you for your guidance on this matter.