Does PSP affect the brain?

Could you elaborate on the potential impact of PSP, or Progressive Supranuclear Palsy, on the brain? Are there specific areas of the brain that are affected, and how does it manifest neurologically? Is there any research that suggests how PSP might disrupt brain function, or any potential treatments that aim to mitigate these effects? Additionally, are there any risk factors or early warning signs that individuals should be aware of to help detect PSP in its earliest stages?