Are all PSPs region free?

Are all Payment Service Providers (PSPs) truly region-free in the realm of cryptocurrency and finance? Is there any nuance or limitation that a global business operating across borders should be aware of when choosing a PSP? For instance, do regulatory frameworks in certain jurisdictions pose barriers for certain PSPs to offer their services seamlessly across the world? And how does the ever-evolving regulatory landscape affect the feasibility of PSPs claiming to be completely region-free?