How can persistence be bad?

How could it be possible that something as seemingly positive as persistence could actually have a negative side? On the surface, persistence is often celebrated as a virtue, synonymous with dedication, hard work, and resilience. But could there be instances where this relentless pursuit of a goal or outcome actually do more harm than good? Perhaps in scenarios where it leads to stubbornness, neglecting other important aspects of life, or continuing down a path that's ultimately unfulfilling or even detrimental. Can you elaborate on how and why persistence can sometimes be a hindrance, rather than a help?