Does APRS use Ctcss?

Could you please clarify if APRS, which I understand to be a system or technology related to Amateur Packet Radio Service, utilizes Continuous Tone-Coded Squelch System, or CTCSS, for its communication protocols? I'm interested in understanding if this specific feature is integrated into APRS for the purpose of reducing interference or enhancing communication efficiency. It would be helpful if you could elaborate on the role of CTCSS in APRS, if any, and any potential benefits or drawbacks associated with its use.