Can zero-knowledge encryption be hacked?

I'm curious, can zero-knowledge encryption really be hacked? It's said to be the holy grail of data protection, ensuring that sensitive information remains secure even if the system itself is compromised. But with hackers constantly evolving their techniques, is it truly invincible? What safeguards does it have in place to prevent unauthorized access? And how does it differ from other encryption methods in terms of its resilience against attacks?