Do enzymes have side effects?

Excuse me, I was wondering if you could elaborate on the potential side effects that enzymes might have? Are there any specific instances where they've been known to cause harm or undesired reactions in the body? I'm particularly interested in understanding the safety profile of enzymes as supplements or in medicinal applications. Could you also discuss any factors that might influence the likelihood of encountering side effects, such as dosage, individual health conditions, or interactions with other medications? Thank you for your time and expertise on this topic.