Do enzymes have a lifespan?

I'm curious to know, do enzymes, those vital molecules that drive countless biological processes, possess a defined lifespan? It's intriguing to consider whether they have a predetermined duration of activity before they cease functioning or if they are capable of indefinite operation, given the right conditions. Understanding the lifespan of enzymes could provide valuable insights into the intricate workings of our cells and potentially lead to groundbreaking discoveries in fields such as medicine and biotechnology. So, do enzymes have a lifespan, or are they perpetual in their ability to catalyze reactions?