Is pure nicotine bad for you?

Is it true that consuming pure nicotine, often found in e-cigarettes and nicotine patches, poses a significant risk to one's health? Are there any potential long-term effects of nicotine intake on the body, such as cardiovascular issues or addiction? How does pure nicotine compare to smoking traditional cigarettes in terms of harmfulness? Are there any benefits to using nicotine replacement therapies, or are they simply a means to prolong addiction? Is there a SAFE level of nicotine consumption, or should individuals aim to avoid it altogether?