What is the largest hacker payout?

Could you elaborate on the notion of the largest hacker payout in the realm of cryptocurrency and finance? Have there been any notable instances where hackers have been rewarded with staggering amounts of digital assets, and if so, what were the circumstances surrounding these payouts? Is there a particular trend or modus operandi that hackers tend to employ in order to secure such substantial rewards? Furthermore, what measures are being taken by the industry and regulatory bodies to prevent such breaches and minimize the potential for hackers to reap such lucrative rewards?