What is Ledger compatible with?

Could you elaborate on the compatibility of Ledger hardware wallets? As a cryptocurrency investor, I'm particularly interested in understanding which cryptocurrencies and software platforms Ledger supports. Do they work with popular wallets like MetaMask or Trust Wallet? Are there any limitations to the number of cryptocurrencies that can be managed on a Ledger device? Additionally, are there any specific requirements or configurations needed for Ledger to work effectively with certain blockchain networks or decentralized applications? Understanding these details will help me make an informed decision on whether to invest in a Ledger hardware wallet.