Can RA weaken your immune system?

The topic of Retinoic Acid (RA) and its potential effects on the immune system has garnered significant attention in recent years. Given its widespread use in dermatological treatments and its ability to regulate cell growth and differentiation, it's natural to wonder if RA can weaken the immune system. Could you elaborate on the current scientific understanding of this relationship? Specifically, what studies have been conducted, and what are the potential risks and mechanisms involved if RA does indeed impact the immune response? Additionally, are there any specific populations or conditions where this effect may be more pronounced?