When to treat osteopenia based on FRAX?

Could you elaborate on when is the appropriate time to consider treatment options for osteopenia, specifically taking into account the FRAX score? Is there a threshold FRAX value that typically triggers intervention? What factors, in addition to FRAX, should clinicians consider when deciding on treatment? Are there any specific patient groups or circumstances where the FRAX score may not be as accurate in predicting fracture risk? What role does patient preference and quality of life considerations play in these treatment decisions?