Is it bad to run 2-stroke gas in a 4-stroke?

Could you elaborate on the potential issues of running 2-stroke gasoline in a 4-stroke engine? It seems like a rather unconventional practice, and I'm curious to know if there are any significant drawbacks or potential damage it could cause to the engine. Does it affect performance, efficiency, or durability in any significant way? I'd appreciate a detailed explanation of the technical differences between these two engine types and how the fuel mismatch could potentially manifest itself.