What are the negatives of osmosis?

Could you please elaborate on the potential drawbacks or negatives associated with osmosis? Are there any specific scenarios where osmosis could be problematic or undesired? Could you provide some examples to further illustrate these negatives? Also, how does osmosis interact with other biological processes and systems? Is there a risk of imbalance or dysregulation when osmosis occurs? I'm interested in understanding the full picture of osmosis, including its potential downsides.