Is it possible to lose money on ETF?

Could you please elaborate on the risks associated with investing in Exchange Traded Funds (ETFs)? Is there a possibility of financial loss when investing in ETFs? And if so, what are the factors that could potentially contribute to such losses? Could market volatility, changes in interest rates, or the performance of the underlying assets affect the value of ETFs in a negative way? Moreover, are there any specific strategies or practices that investors should be aware of to mitigate the risks and protect their investments? I'm keen to understand the potential downsides of ETF investing to make informed decisions.