Is helium safe to use?

Could you please elaborate on the safety aspect of using helium? I'm curious to know if it poses any potential hazards or risks when handled or utilized. Is it safe for both indoor and outdoor applications? Are there any specific safety measures that should be taken while using helium? Also, is it environmentally friendly, and does it have any negative impact on the surrounding ecosystem? I'm interested in understanding the overall safety profile of helium usage.