What will replace helium?

Could you please elaborate on the question, 'What will replace helium?'? Given the unique properties of helium, such as its lightness and inertness, I'm curious to know what alternative substances might be considered as potential replacements. Could you provide some examples of substances that might fulfill similar functions or have comparable characteristics? Also, are there any specific applications or industries where the search for a helium substitute is particularly urgent or significant? Understanding the context and motivations behind this inquiry would greatly assist in formulating a comprehensive answer.