What is the biggest problem with CRISPR?

Could you elaborate on the central issue surrounding CRISPR technology? I'm particularly interested in understanding what the most significant challenge or problem associated with it is. Could you explain in detail the nature of this problem and perhaps discuss its potential impact on the field of genetics and biotechnology? Additionally, are there any ongoing efforts or strategies being pursued to address this challenge? I'm keen to learn more about the current status and potential solutions to this pressing issue.