How do you activate a rune?

Could you please elaborate on the process of activating a rune? I'm particularly interested in understanding the steps involved and any specific requirements that might be necessary. Could you also explain what kind of effects or powers a rune typically unleashes once it's been activated? Is there a certain ceremony or ritual that needs to be performed? Additionally, are there any safety measures one should take into account while attempting to activate a rune? I'm eager to learn more about this fascinating topic.